Resveratrol and Quercetin support blood sugar levels and mimic calorie restriction for healthy weight loss.
What’s the secret to staying slim, healthy, and young?
The French smoke, drink and eat lots of cheese. Yet, despite eating a diet that’s relatively high in fat, French women are the slimmest in Europe. The average French woman weighs 137.6 pounds. Compare that to the average 168-pound American woman in America.1 The French also enjoy one of the lowest rates of heart disease in the world. This contradiction has been coined “the French paradox,” and is believed to be partly due to eating a Mediterranean-based diet, drinking red wine, exercising, and walking a lot. 2
The Mediterranean diet is considered one of the healthiest dietary patterns thanks to a combination of foods rich in antioxidants and anti-inflammatory nutrients. And the antioxidants in red wine have been touted by scientific studies to have anti-inflammatory and blood lipid regulating effects. 3,4 Resveratrol and Quercetin combined may produce similar results.
But you don’t have to drink wine to gain the benefits. Resveratrol dietary supplements offer an easier, healthier way . . . without the added sugar, carbs, and calories.
Resveratrol is a polyphenol found in red grapes, red wine, blueberries, strawberries, blackberries, tomatoes, peanuts, and cocoa. It has antioxidant and anti-inflammatory properties, which hundreds of studies have shown to provide cardiovascular and anti-aging benefits. 5-11
- Supports healthy blood flow and circulation by relaxing the endothelium (lining of the arteries) 5
- Increases HDL, the “good” cholesterol 6
- Lowers LDL, the “bad” cholesterol 6
- Supports healthy cognition 7
- Delays cellular aging by activating sirtuins, an anti-aging regulator 7
- Supports the immune system 8
- Supports healthy blood glucose levels and insulin sensitivity 9,10
- Supports cognitive function 11,12
When RESVERA Q™ ANTI-AGING is taken along with WeBlume’s REJUV NMN™ ESSENTIAL, the resveratrol acts as an accelerator to speed up the pace at which sirtuins work.
Clinical evidence suggests that resveratrol is able to improve cerebral blood flow, reduce neuron inflammation and improve cognitive performance. In one study, healthy adults aged 50-75 years, who took resveratrol every day for 26 weeks improved their ability to complete memory tasks. 11,12
Telomeres are the protective caps at the tips of chromosomes. Their job is to protect our DNA, but they shorten as we age. Since there’s a direct correlation between telomere length and life expectancy, stress, and the onset of age-related diseases, it’s important to make an effort to maintain their length. 13
The good news is that resveratrol penetrates the cells’ nucleus and increases our body’s production of telomerase, the enzyme that helps lengthen telomeres. 14
Resveratrol is a phytoestrogen — plant-based estrogen — that acts like the female hormone estrogen. Phytoestrogens have been shown to have a positive effect on mood and mental performance in women during menopause when estrogen levels begin to decline. 15
A study of 40 postmenopausal women with a high body mass index (over 25) found that a daily 1 gm dose of resveratrol has favorable effects on estrogen metabolism.16
Protects against insulin resistance
Quercetin is a flavonoid (plant pigment) found in plants and foods including red wine, onions, green and black tea, apples, berries, and some leafy green vegetables and beans. Its powerful antioxidant and anti-inflammatory activities are well documented. 17
- Provides strong antioxidant support 18
- Produces anti-inflammatory effects, inhibiting the release of histamine 18
- Offers a cardioprotective effect 19
- Helps lower LDL oxidation when used in combination with resveratrol 19
- Inhibits intestinal glucose absorption 20,21
- Improves glucose utilization in peripheral tissues 20, 21
- Lowers glucose levels 20, 21
- Helps protect against insulin resistance 22,23
What is Insulin Resistance?
When we eat a diet high in processed carbohydrates, are stressed and sleep poorly, live a sedentary lifestyle, and have chronic health issues such as cardiovascular disease, the body can become insulin resistant. When this happens, the peripheral tissue cells lose their sensitivity to insulin, and the pancreas begins to produce excess insulin. This leaves glucose and other nutrients that are not absorbed circulating in the bloodstream. When this happens, you pump out more and more insulin, become more resistant to its effects, and end up with insulin resistance. Eventually, the pancreas becomes overburdened and starts making less insulin. That’s when things go from bad to worse, and you can end up with serious blood glucose issues.
How does quercetin help?
In a number of laboratory animal studies, a combination of quercetin and resveratrol showed the potential for improving blood glucose processes in humans, including insulin resistance. 22
Supports healthy fat metabolism and weight control
BioPerine® is a patented extract of black pepper fruit that contains a 95% piperine content. Peperine is the active ingredient in black pepper, which is one of the most widely used spices in the world. But it’s used for more than just flavor. Scientists have discovered that piperine provides a number of therapeutic health benefits.
- Provides antioxidant effects 23
- Stimulates pancreatic digestive enzymes 23
- Reduces gastrointestinal food transit time 23
- Decrease intestinal absorption of dietary cholesterol 23, 24
- Supports healthy blood lipid levels 23, 24
- Supports healthy weight by blocking fat absorption 25
- Supports cardiovascular function 26, 27
Is RESVERA Q™ ANTI-AGING safe:
Yes! But piperine may increase the absorption of some drugs, so if you are on a prescription drug, check with your physician first.
- Hales CM, Carroll MD, Fryar CD, Ogden CL. Prevalence of obesity and severe obesity among adults: United States, 2017–2018. NCHS Data Brief, no 360. Hyattsville, MD: National Center for Health Statistics; 2020.
- Ferrières J. The French paradox: lessons for other countries. Heart. 2004 Jan;90(1):107-11. doi: 10.1136/heart.90.1.107. PMID: 14676260; PMCID: PMC1768013.
- Sofi F, Cesari F, Abbate R, Gensini GF, Casini A. Adherence to Mediterranean diet and health status: meta-analysis. BMJ. 2008 Sep 11;337:a1344. doi: 10.1136/bmj.a1344. PMID: 18786971; PMCID: PMC2533524.
- Tedesco I, Spagnuolo C, Russo GL, Russo M, Cervellera C, Moccia S. The Pro-Oxidant Activity of Red Wine Polyphenols Induces an Adaptive Antioxidant Response in Human Erythrocytes. Antioxidants (Basel). 2021 May 18;10(5):800. doi: 10.3390/antiox10050800. PMID: 34070135; PMCID: PMC8158335.
- Das M, Das DK. Resveratrol and cardiovascular health. Mol Aspects Med. 2010 Dec;31(6):503-12. doi: 10.1016/j.mam.2010.09.001. Epub 2010 Sep 15. PMID: 20837050.
- Katalin Fodor, Delia Mirela Tit, Bianca Pasca, Cristiana Bustea, Diana Uivarosan, Laura Endres, Ciprian Iovan, Mohamed M. Abdel-Daim, Simona Bungau, “Long-Term Resveratrol Supplementation as a Secondary Prophylaxis for Stroke”, Oxidative Medicine and Cellular Longevity, vol. 2018, Article ID 4147320, 10 pages, 2018. https://doi.org/10.1155/2018/4147320
- Moraes DS, Moreira DC, Andrade JMO, Santos SHS. Sirtuins, brain and cognition: A review of resveratrol effects. IBRO Rep. 2020 Jun 26;9:46-51. doi: 10.1016/j.ibror.2020.06.004. PMID: 33336103; PMCID: PMC7733131.
- Malaguarnera L. Influence of Resveratrol on the Immune Response. Nutrients. 2019 Apr 26;11(5):946. doi: 10.3390/nu11050946. PMID: 31035454; PMCID: PMC6566902.
- Springer M, Moco S. Resveratrol and Its Human Metabolites-Effects on Metabolic Health and Obesity. Nutrients. 2019 Jan 11;11(1):143. doi: 10.3390/nu11010143. PMID: 30641865; PMCID: PMC6357128.
- Gambini, J et al. “Properties of Resveratrol: In Vitro and In Vivo Studies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans.” Oxidative medicine and cellular longevity vol. 2015 (2015): 837042. doi:10.1155/2015/837042
- A. Veronica Witte, Lucia Kerti, Daniel S. Margulies, Agnes Flöel Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults. Journal of Neuroscience 4 June 2014, 34 (23) 7862-7870; DOI: 10.1523/JNEUROSCI.0385-14.2014. https://www.frontiersin.org/article/10.3389/fnagi.2014.00218
- Rege Shraddha D., Geetha Thangiah, Griffin Gerald D., Broderick Tom L., Babu Jeganathan Ramesh. “Neuroprotective effects of resveratrol in Alzheimer disease pathology.” Frontiers in Aging Neuroscience, Vol 6, 2014, pgs. 218.
- Nikolina Škrobot Vidaček, Lucia Nanić, Sanda Ravlić, Mary Sopta, Marko Gerić, Goran Gajski, Vera Garaj-Vrhovac, Ivica Rubelj, Telomeres, Nutrition, and Longevity: Can We Really Navigate Our Aging?, The Journals of Gerontology: Series A, Volume 73, Issue 1, January 2018, Pages 39–47, https://doi.org/10.1093/gerona/glx082
- Pyo IS, Yun S, Yoon YE, Choi JW, Lee SJ. Mechanisms of Aging and the Preventive Effects of Resveratrol on Age-Related Diseases. Molecules. 2020;25(20):4649. Published 2020 Oct 12. doi:10.3390/molecules25204649
- Chow, HH.S., Garland, L.L., Heckman-Stoddard, B.M. et al. A pilot clinical study of resveratrol in postmenopausal women with high body mass index: effects on systemic sex steroid hormones. J Transl Med 12, 223 (2014). https://doi.org/10.1186/s12967-014-0223-0
- Valentina, Echeverria Florencia, Barreto George E., Echeverria Javier, Mendoza Cristhian. “Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause.” Frontiers in Pharmacology. Vol 12, 2021, pgs. 993 https://www.frontiersin.org/article/10.3389/fphar.2021.644103 DOI=10.3389/fphar.2021.644103
- Fraga CG , Croft KD , Kennedy DO , Tomás-Barberán FA . The effects of polyphenols and other bioactives on human health. Food Funct. 2019 Feb 20;10(2):514-528. doi: 10.1039/c8fo01997e. PMID: 30746536.
- Brüll V, Burak C, Stoffel-Wagner B, et al. Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-)hypertension: a randomised double-blinded placebo-controlled cross-over trial. Br J Nutr. 2015;114(8):1263-1277. doi:10.1017/S000711451500295
- Eid HM, Haddad PS. The Antidiabetic Potential of Quercetin: Underlying Mechanisms. Curr Med Chem. 2017;24(4):355-364. doi: 10.2174/0929867323666160909153707. PMID: 27633685.
- Yang DK, Kang HS. Anti-Diabetic Effect of Cotreatment with Quercetin and Resveratrol in Streptozotocin-Induced Diabetic Rats. Biomol Ther (Seoul). 2018;26(2):130-138. doi:10.4062/biomolther.2017.254
- Arias N, Macarulla MT, Aguirre L, Martínez-Castaño MG, Portillo MP. Quercetin can reduce insulin resistance without decreasing adipose tissue and skeletal muscle fat accumulation. Genes Nutr. 2014;9(1):361. doi:10.1007/s12263-013-0361-7
- Zhao L, Cen F, Tian F, et al. Combination treatment with quercetin and resveratrol attenuates high fat diet-induced obesity and associated inflammation in rats via the AMPKα1/SIRT1 signaling pathway. Exp Ther Med. 2017;14(6):5942-5948. doi:10.3892/etm.2017.5331
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- Duangjai A, Ingkaninan K, Praputbut S, Limpeanchob N. Black pepper and piperine reduce cholesterol uptake and enhance translocation of cholesterol transporter proteins. J Nat Med. 2013 Apr;67(2):303-10. doi: 10.1007/s11418-012-0682-7. Epub 2012 Jun 27. PMID: 22736065.
- Park UH, Jeong HS, Jo EY, Park T, Yoon SK, Kim EJ, Jeong JC, Um SJ. Piperine, a component of black pepper, inhibits adipogenesis by antagonizing PPARγ activity in 3T3-L1 cells. J Agric Food Chem. 2012 Apr 18;60(15):3853-60. doi: 10.1021/jf204514a. Epub 2012 Apr 6. PMID: 22463744.
- Badmaev V, Majeed M, Prakash L. Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation. J Nutr Biochem. 2000 Feb;11(2):109-13. doi: 10.1016/s0955-2863(99)00074-1. PMID: 10715596.
- Heying Pei, Linlin Xue, Minghai Tang, Huan Tang, Shuang Kuang, Lun Wang, Xu Ma, Xiaoying Cai, Yan Li, Min Zhao, Aihua Peng, Haoyu Ye, and Lijuan Chen. Alkaloids from Black Pepper (Piper nigrum L.) Exhibit Anti-Inflammatory Activity in Murine Macrophages by Inhibiting Activation of NF-κB Pathway. Journal of Agricultural and Food Chemistry 2020 68 (8), 2406-2417. DOI: 10.1021/acs.jafc.9b07754