Full list of Mr. Irrelevants in NFL draft history: Is Brock Purdy already the best final pick? He has had 11 passes batted down at the line of scrimmage, six more than any quarterback in the NFL this season. Additionally, ESPN Stats & Information provides a big stat to know and a betting nugget for each contest, and our Football Power Index (FPI) goes inside the numbers with a matchup rating (on a scale of 1 to 100) and a game projection. FPI prediction: SF, 72.5% (by an average of 8.3 points), Matchup must-reads: Chubb's running finally launches Browns' offense How good are first-place 49ers? -- Lindsey Thiry. Walder's pick: Chargers 24, Browns 20 Russell Wilson's QBR in five road games against the Rams is 48.6 compared with 71.5 in his 37 other road games. Patrick Mahomes has been as good against the Raiders as any opponent, with a 7-1 record, 22 touchdowns and just three interceptions. See Week 5 rankings. And the Washington passing attack? He is the first player with nine sacks through the first four games of a season since Kabeer Gbaja-Biamila recorded nine in 2001. The Week 5 NFL slate is stacked with great matchups. Our NFL Nation reporters bring us the biggest keys to every game and a bold prediction for each matchup. (1:06). NFL DRAFT HISTORY & NOTES. HOU-JAX | SF-CAR | PHI-ARI passing windows despite a smaller 5-foot-10, 204-pound frame. His 43.1 QBR this season is also his worst through the first four games in that same time frame. Spread: GB -8.0 (41), What to watch for: This could be a nightmare matchup for the Packers' defense. Josh McCown has completed 75 percent of his passes against the blitz, which bodes well against the blitz-heavy Browns, who have allowed a 127 passer rating when blitzing. 2022 NFL Expert Picks | ESPN -- Marcel Louis-Jacques. Since Alex Smith got injured in Week 11 of last season, it has had an NFL-high five starting QBs. Matchup rating: 50.5 | Spread: BAL -3.5 (44), What to watch for: The Ravens' defense has a penchant for giving up big plays. Colts 21, 49ers 17 -- Mike Wells, Marcus Mariota's playing status could be unknown until Sunday, but the Titans have problems to solve even if he does find a way to play. It's all here to help get you ready for a loaded weekend of NFL football. But this week, players and coaches have been quick to say that was one game and the Chiefs present a different challenge. If the Titans can't run, they are in trouble against the Dolphins, especially with the uncertainty of Mariota (hamstring). The Falcons rank seventh in the NFL in passing defense per game and have allowed a receiver to top 100 receiving yards in just one of their first four games. Eagles 27, Cardinals 17 -- Josh Weinfuss, Larry Fitzgerald long has tortured the Eagles, averaging six catches, 99 yards and more than a touchdown per game against them in seven meetings. The Packers opened the season with a disastrous loss at New Orleans . But Minnesotas defense is tough. Betting nugget: Bridgewater is 25-7 against the spread (ATS) in his career as a starting quarterback, the best mark by any QB with at least 15 starts in the Super Bowl era. What to know for fantasy: Henry didn't catch a single pass in the first two weeks but has eight (for 91 yards) over the past two weeks. Including playoffs, Rodgers has thrown 29 touchdown passes with just eight interceptions in 15 games. However, Arizona's primary hope for winning this game lies with its run defense. -- Tim McManus. Depth charts for every team ET | CBS What to know for fantasy: Barkley has more than 20 carries or a rushing TD in all four games this season and leads the league in percentage of team offense accounted for (40.4%). See Week 5 rankings. That'll help the Texans continue their eight-game winning streak over the Jaguars. Moody's pick: 49ers 27, Panthers 10 Barshop's pick: Texans 20, Falcons 17 2023 NFL Draft live tracker: 4th through 7th round picks, analysis How have point spreads moved for Week 5 as Sunday approaches? 1 min read. They haven't lost three straight road games since 2018. It prompted Packers coach Matt LaFleur to say this week that defensive coordinator Joe Barry needs to have his players "play more physical" and "in certain situations you might have to put an extra defender in the box." The Eagles' pass defense is vulnerable, but Luke Falk -- a dink-and-dunk passer -- doesn't have enough arm to exploit the matchup. Lions 28, Panthers 20 -- Michael Rothstein, This is the second of three consecutive road games for the Niners, and they're coming off a trio of games they lost by a combined eight points. Walder's pick: Eagles 23, Cardinals 20 Overall, Minnesota is tied for eighth in points allowed (19.0) and third in rushing yards allowed (71.3). Projecting the Giant's first-round pick, Moody's pick: Saints 27, Seahawks 24 It sounds crazy, but the Jets will win their third straight game. The Bengals are allowing 8.6 yards per attempt, which is ideal for a team averaging 5.5 despite having Kyler Murray -- who has thrown for 300 yards in two of his first four games. Jets' high-priced, underperforming offensive line receives wake-up call Eagles RBs coach Duce Staley: 'A lot of Jordan and a lot of Miles', 1 p.m. NFL picks, predictions for Week 5 Los Angeles Rams (-1.5) at Seattle Seahawks Thursday, 8:20 p.m., FOX/NFL Network The NFC West grinder continues. FPI prediction: CHI, 63.5% (by an average of 4.8 points), Matchup must-reads: Mack expected to be with the Raiders 'for the long haul' Daniel embraces seldom-used, uncertain backup QB life Roquan Smith says he's playing Sunday Carr: Burfict's 'heart is broken;' QB says ban isn't fair, 1 p.m. NFL Week 5 game picks, schedule guide, fantasy football tips - ESPN The team has preached all week that their offense won't change much with the backup quarterback starting, and he'll prove them right come Sunday. Not super bold, but scoring even just a little over 30 points will be enough for the Chiefs to win. The NFL reporter use his Twitter account to share insight about the league's upcoming 2023 schedule . See Week 5 rankings. McManus' pick: Steelers 24 . This one could be decided by which quarterback is upright at the end of the afternoon. NFL Nation reporters give their picks for Week 5, including whether the Cowboys can bounce back against Aaron Rodgers and the Packers. Week 5 NFL game picks, schedule guide, fantasy football tips and - ESPN This week's draft seemingly begins with the second overall pick -- excluding Tuesday's wild odds move for the top pick -- but it could take a few wild turns right after that. The Bucs also gave up an uncharacteristic 189 rushing yards in their 41-31 loss to the Kansas City Chiefs last week -- the most they've surrendered since 2018. Sure, the Packers have found replacements for all three, but those were big-time players who performed in the clutch. See Week 5 rankings. NFL Week 5 Expert Picks - Straight Up - CBS Sports Read more. Read more. That will make it even harder for the Jaguars to do much in the passing game, especially downfield, to open things up for RB Leonard Fournette. Read more. They've gone 21 straight possessions without a score, and that number will reach the high 20s. Stat to know: Joe Burrow has 12 touchdowns on passes of 20-plus yards downfield since the start of last season. -- Nick Wagoner, Embracing the fun spirit of fantasy sports, ESPN senior fantasy analyst Matthew Berry and his unconventional cast of characters aim to make fantasy football players smarter and help them win their leagues. Walder's pick: 49ers 23, Panthers 14 So, these teams could have to rely on their defenses. Matchup rating: 42.5 | Spread: MIN -5.5 (43.5), What to watch for: How will Kirk Cousins perform vs. the Giants' 25th-ranked pass defense, which is allowing 279.5 yards per game. The Saints' problems are beyond the quarterback right now, as they are among the worst teams in the league in both penalties and turnover differential. Baltimore's defense has struggled, and the amount of damage opposing teams have done through the air bodes well for the Bengals and Chase, who has received extra attention from opposing teams this season. Among those players, no one is averaging fewer fantasy points per touch than Sony Michel (0.44). They have the NFL's second-ranked rushing defense, surrendering only 59.3 yards per game, and they held Christian McCaffrey to just 37 rushing yards in Week 2 (53 all-purpose yards) and the Rams to just 28 total rushing yards in Week 4. Chuck Pagano has never started a season 1-4 as coach of the Colts. It wouldn't be a shock if they underestimate the Browns, but they have too many matchups in their favor to lose the game. But the Commanders' run defense will be severely tested by Tennessee running back Derrick Henry. Jets 24, Browns 10 -- Pat McManamon, The Lions are strong against the run, which makes the timing of Panthers quarterback Cam Newton finding his timing against New England most important. What to know for fantasy: Derrick Henry has nine straight games with either over 100 total yards or a rushing touchdown. Betting nugget: Mahomes is 7-1 outright and 6-2 ATS against Las Vegas. Stat to know: Geno Smith has a 77.3 completion percentage this season, the highest by any QB through a team's first four games of a season in NFL history (min. Read more. Atlanta has rushed for at least 179 yards in three of its four games. -- Rich Cimini. The Jags likely won't have cornerback Jalen Ramsey, and the domino effect of his absence will be a major issue when McCaffrey lines up on the outside. Expect the Raiders' overachieving defense to make a play or two -- paging Khalil Mack and his four sacks -- to jump-start the offense, and all will be right in Silver and Blackdom for a week, at least. His six catches last week against the Chargers are 60% of his grabs for the season. Even at full strength, Seattle's offensive line will have its hands full against a Rams front four that has given the Seahawks all sorts of trouble during the past few seasons. The Chargers are 2-6 when the Broncos have intercepted Rivers at least twice and 5-11 when Denver has intercepted him at least once. ESPN Reporter Claims Aaron Rodgers Deal Affected NFL Schedule Release What to know for fantasy: Murray leads the NFL with 187 opportunities this season (pass-plus-rush attempts). NFL Week 5 Early Odds, Picks & Predictions (2022) | BettingPros On the other side of the ball, Tom Brady said his shoulder is fine, but former Falcon Julio Jones' status is up in the air after missing the second half last week because of a knee injury. Read more. What to know for fantasy: After scoring 11 times in his first 14 games last season, Hopkins has scored just twice in his past seven games (playoffs included). Read more. Inside Jets' trade pursuit of Tyreek Hill, and how they rebounded Dolphins say QB Tua Tagovailoa ruled out for Week 5 game vs. New York Jets, What to watch for: Justin Herbert finished with 398 passing yards in the Chargers' win over the Browns last season, the most Cleveland surrendered in any game in 2021. See Week 5 rankings. ET | CBS QB Teddy Bridgewater is 2-0 lifetime against the Jets, who look to go over .500 for the first time since a 1-0 start in 2018. See Week 5 rankings. Newton's pick: Panthers 21, Jaguars 17 Betting nugget: The past four times Jacksonville was a favorite, it lost the game outright, with three of those losses coming against Houston. Walder's pick: Jaguars 31, Texans 9 -- Marcel Louis-Jacques. Rams 23, Seahawks 20 -- Alden Gonzalez, The Ravens catch a break with EJ Manuel starting at quarterback for the injured Derek Carr. We answered the biggest post-draft question for all 32, LB Barrett's 2-year-old daughter drowns in pool, Deion 'ashamed' after only 1 HBCU player drafted, Sources: NFL eyes May 11 to release schedule, Teams set NFL record with 43 trades during draft, Jets coach Saleh: Rodgers making 'presence felt', Cowboys scout emotional as team drafts his son, Rams use 'Mr. Vikings 27, Bears 26 -- Jeff Dickerson, Cowboys' running game will be tested on Sunday (1:06), Week 5 NFL predictions: Scores for every game, Dolphins' Jaelan Phillips, teammates inspired by mentoring incarcerated teens, What adding Odell Beckham Jr. would mean for the New York Jets, Extending Vikings star Justin Jefferson: what it could cost, possible sticking points. Stat to know: Cincinnati's Joe Mixon is averaging a career-low 3.2 yards per rush and 37.3 yards per game this season. For the season on third downs, he's completing only 48.9% of his passes and owns a 78.0 passer rating. -- Brooke Pryor. -- Michael Rothstein. -- John Keim, Bold prediction: Titans quarterback Ryan Tannehill will finish with 300 passing yards in a win over the Commanders. -- Jamison Hensley. Spread: PHI -5.0 (49.5), What to watch for: The Cardinals will have their work cut out for them passing and defending the ball. IND-KC | CLE-SF, 1 p.m. Week 5 brings some more great matchups and potential upsets. Levis opens up about draft day Stat to know: Tampa Bay's Shaquil Barrett leads the NFL with 9.0 sacks through four games. Jets' high-priced, underperforming offensive line receives wake-up call, Eagles RBs coach Duce Staley: 'A lot of Jordan and a lot of Miles', Fournette flourishes in Christian McCaffrey-type workload, Amid defensive changes, Kuechly remains the Panthers' stopper, Jaguars looking to cash in on Minshew mania, Cardinals WR Kirk likely out Sunday but ankle better, Bengals put WR Ross on IR with shoulder injury, Broncos' 'world of suck' won't be easily fixed, How Chargers kept team from splintering during Gordon holdout, Chubb's injury further exposes Broncos' house of cards, Elliott took poor game personally, aims to rebound vs. Packers, The Graham mistake 2.0: TE a rare miss for Packers GM, With Elliott next, Packers have to get run defense on track in a hurry, Leighton Vander Esch's star rising as fast off field as on it, For Randall Cobb, Packers game just another week, Mahomes, Favre and other NFL stars reveal the larger-than-life tales behind Andy Reid, Colts GM Chris Ballard has needed his no-flinch, no-panic approach, Chiefs RB Williams has waited behind big-name backs before, Ebron 'disgusted' by drops, takes blame for Colts' loss, Chubb's running finally launches Browns' offense, How good are first-place 49ers?